
Drinking beverages containing artificial sweeteners like high-fructose corn syrup and aspartame is associated with the development of metabolic syndrome and obesity. Researchers at Alexandria University and Damanhour University in Egypt hypothesized that inflammatory cytokines play a role in lipid storage and induction of liver injury. They looked at the expression of adipocytokines and its link to liver damage.
To test their hypothesis, rats in the study received water, cola soft drink, and aspartame every day for two months. Then, the researchers measured the rats' lipid profiles, liver antioxidants and pathology, and mRNA expression of adipogenic cytokines. Based on their analysis, the rats that received soft drink and aspartame exhibited high levels of glucose, triacylglycerol, low-density lipoprotein, and very low-density lipoprotein cholesterol, as well as obvious visceral fatty deposition. These resulted in metabolic syndromes including hyperglycemia and hypertriacylglycerolemia. In addition, soft drink and aspartame intake also increased transaminases and induced changes in the antioxidant status of the rats' liver, increasing oxidative stress and reducing antioxidant levels – all of which are indicative of oxidative liver damage. The researchers also saw degeneration, infiltration, necrosis, and fibrosis in the liver of rats, especially those that received aspartame. From these findings, the researchers concluded that long-term consumption of soft drink or aspartame causes liver damage. (Related: An hour is all it takes: Drinking a can of soda ‘overloads’ the body with sugar and damages it in just 60 minutes.)Elderly population suddenly dying off for unexplained reasons, and it’s no longer coded as covid-19
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