- Earlier studies on chestnut flower extract (CCDF) found that it contained antioxidant and anti-melanogenic properties.
- For this study, the team looked at how CCDF affects adipocyte differentiation using 3T3-L1 cells. They also looked at the bioactive compound in CCDF for the cell differentiation process.
- While CCDF absolute did not change 3T3-L1 cell viability, it reduced lipid cell build-up in 3T3-L1 cells induced in the 3-isobutyl-1-methylxanthine/dexamethasone/insulin (MDI) medium.
- The gas chromatography-mass spectrometry results revealed that CCDF absolute had 10 compounds. Of the 10 compounds, cinnamyl alcohol (3-phenyl-2-propene-1-ol) exhibited dose-dependent inhibition on lipid cells in the MDI-contained 3T3-L1 cells with a concentration range between 0.1 micrograms per milliliter (mcg/mL) to 10 mcg/mL without signs of cytotoxicity.
- Inhibition was particularly significant at 5 mcg/mL (70.27 ±1.50 percent response rate in MDI-alone treatments) and 10 mcg/mL (28.94 ±1.76 percent response rate in MDI-alone treatments)
- Cinnamyl alcohol (5 and 10 mcg/mL) attenuated enhanced expression of obesity-related proteins, including PPARy, C/EBPa, SREBP-1c, and FAS.
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