According to authors, people need to consume sufficient amounts of vitamin C to alleviate endotoxemia and consequent pro-inflammatory responses that give rise to metabolic disorders. Endotoxemia – the presence of endotoxins in the blood – is associated with an increase in the absorption of bacteria and gut-derived endotoxins, such as lipopolysaccharide (LPS). LPS triggers gut and liver inflammation. When the gut barrier function is impaired due to excessive dietary energy (caloric) intake, metabolic endotoxemia occurs, followed immediately by inflammation. These events impair vitamin C absorption, which, together with impaired gut barrier function, can be seen in people with metabolic syndrome.
In order to prevent this, adequate vitamin C status should be maintained. People can avoid suffering from endotoxemia and inflammation in the gut and liver by improving their vitamin C status. This will also prevent chronic inflammation and oxidative damage, which can induce insulin resistance and the development of related metabolic disorders.
Vitamin C is a powerful antioxidant that strengthens the immune system. Having a strong immune system helps lower the risk of chronic diseases, such as heart disease and cancer. Vitamin C can also reduce the risk of heart disease by lowering high blood pressure and decreasing the levels of low-density lipoprotein (LDL) and triglycerides.
As an antioxidant, vitamin C helps repair tissue and reduces damage from inflammation and oxidation. People with adequate vitamin C levels are believed to have stronger immunity against infections compared with those who are vitamin C-deficient. Vitamin C may also help protect against acute respiratory infections, especially in people with malnutrition and those who are physically stressed. In addition, vitamin C plays an important role in the production of collagen, L-carnitine, and some neurotransmitters. It also helps metabolize proteins.
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