Pourthiaea villosa has antioxidant properties that protect human dermal fibroblasts from skin aging
By dominguez // 2020-09-08
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In this study, researchers from South Korea and the U.S. investigated the antioxidant properties of Pourthiaea villosa (oriental photinia) extract. Their findings were published in the Journal of Medicinal Food.
  • Skin aging is linked to an increased production of reactive oxygen species (ROS) by human cells.
  • Because they are the main contributors to premature aging, skin cells have developed antioxidant enzymes to protect themselves from the damage caused by ROS.
  • Antioxidants play a critical role in preventing the signs of ROS-induced aging.
  • The researchers treated human dermal fibroblast (HDF) cells with the P. villosa extract (PVDE) to evaluate its antioxidant and anti-aging activities, and to determine the mechanisms behind them.
  • They reported that PVDE showed significant antioxidant effects based on evaluations of its reducing power and ABTS and DPPH radical scavenging activity.
  • PVDE also significantly increased the expression of antioxidant enzymes and effectively blocked H2O2-induced matrix metalloproteinase activity by influencing the MAPK signaling pathways in HDFs.
  • PVDE was found to contain active compounds like polyols, phenolic compounds and flavonoids.
Based on these findings, the researchers concluded that PVDE has potent antioxidant and anti-aging effects that can promote skin health. Journal Reference: Choi SI, Lee JS, Lee S, Cho BY, Choi SH, Han X, Sim W-S, Kim YC, Lee BY, Kang IJ et al. PROTECTIVE EFFECTS AND MECHANISMS OF POURTHIAEA VILLOSA (THUNB.) DECNE. EXTRACT ON HYDROGEN PEROXIDE-INDUCED SKIN AGING IN HUMAN DERMAL FIBROBLASTS. Journal of Medicinal Food. 06 August 2019;22(8):841–850. DOI: 10.1089/jmf.2018.4379
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