The Dietary Guidelines for Americans suggest eating fish at least twice a week. Salmon is a good source of omega-3 fatty acids which have positive lipid-modifying effects, but it is unknown whether these effects are dose-dependent.
In the study, researchers at Grand Forks Human Nutrition Research Center, the University of Minnesota, and the University of North Dakota looked at the effect of Atlantic salmon intake on lipoprotein particle size and concentration associated with cardiovascular disease risk. They hypothesized that low-density lipoprotein (LDL) particle size and high-density lipoprotein (HDL) particle size and concentration would increase with salmon intake in a dose-dependent manner.
To test their hypothesis, the researchers recruited 19 overweight adults who were then randomly assigned to consume 90, 180, or 270 grams (g) of Atlantic salmon twice a week for four weeks. Following a four- to eight-week washout, participants crossed over to another dose of fish intake until all treatments were completed. While the researchers used Atlantic salmon for the study, it is important to remember that this type of salmon is mostly farmed. When buying salmon, it is better to choose wild-caught ones. (Related: Here’s why wild-caught is better than farm-raised salmon: It has a more diverse nutritional profile.)
The results showed that consumption of salmon reduced plasma and serum triglyceride levels and increased plasma HDL cholesterol levels. It also reduced very low-density lipoprotein (VLDL) particle and chylomicron particle, while LDL particle concentrations were increased in a dose-dependent manner. The mean size of VLDL particle was reduced, while that of LDL increased. As total triglyceride was reduced, the triglyceride content of VLDL particle and chylomicron particle also dropped. These findings indicated that consuming salmon twice every week affects lipoprotein particle size and concentration in a manner linked to cardiovascular disease risk reduction.Study: Ashwagandha extract can be used to improve sleep quality and relieve stress
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