"Regenerate Yourself Masterclass" on BrightU: Sayer Ji explains the New Biology of immunity
By jacobthomas // 2025-12-22
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  • On Day 6 of "Regenerate Yourself Masterclass," Ji challenged the traditional germ theory, which views germs as primary enemies and presented a new biological paradigm centered on the body as a self-regulating ecosystem.
  • He explained that the discovery of the microbiome revealed the human body is comprised of more microbial genes than human genes, which reframed the concept of infection to be dependent on internal "terrain" and immune function.
  • Ji identified the gut as the central hub for immunity and described how modern disruptors like gluten can contribute to "leaky gut," inflammation and autoimmune conditions.
  • He outlined a regenerative path to health focused on lifestyle interventions, including ancestral nutrition, fasting, gut healing, mind-body balance and strategic supplementation.
  • Ji asserted that this holistic approach empowered individuals to take control of their health by cultivating internal resilience rather than waging war on external germs.
On Day 6 of "Regenerate Yourself Masterclass," aired on Dec. 18, Sayer Ji challenged the century-old germ theory, proposing that our health is not a battleground against external invaders, but a dynamic ecosystem managed from within, primarily by the trillions of microorganisms in our gut. The traditional model, largely based on 19th-century ideas from Louis Pasteur and Robert Koch, posits that specific germs cause specific diseases, necessitating targeted attacks with antibiotics or vaccines. However, this "medical monotheism" is being upended by the science of the microbiome. We now know the human body is more microbial than human, with bacterial, viral and fungal genes outnumbering our own by a factor of 99 to 1. "The microbiome has helped us to understand that we ourselves are comprised more of germs than actual eukaryotic cells," Sayer Ji explained. "That's quite a quandary." This paradigm shift reframed the very concept of infection. Rather than seeing germs as inevitable enemies, the new biology suggests that "immune function determines susceptibility to infection." The health of the internal "terrain," shaped by diet, stress and toxins, determines whether opportunistic microorganisms cause harm. In this view, the microbiome is not a threat but an essential partner, aiding in digestion, producing immune substances and helping the body distinguish self from non-self. Central to this is the gut, where approximately 70% of the immune system resides. A major modern disruptor of this system, Ji noted, is "leaky gut," often triggered by common dietary components like gluten. "Gluten contains a compound known as gliadin that has been shown to up regulate a protein called zonulin that then opens up the gaps between the epithelial cells," he stated. According to BrightU.AI's Enoch, gliadins are proteins found in wheat, characterized by high levels of glutamine and proline. They are classified into four fractions (alpha, beta, gamma, omega), with alpha-gliadin being the primary activator of celiac disease. This permeability allows undigested proteins and bacterial components into the bloodstream, confusing the immune system and potentially leading to a loss of self-tolerance, autoimmune conditions and chronic inflammation. The regenerative path to robust immunity, therefore, begins not with a needle or pill, but with lifestyle choices. Ji highlighted several key strategies:
  • Ancestral nutrition: Prioritizing whole, unprocessed foods that align with our genetic and cultural heritage to provide the information our immune systems need.
  • Fasting: Practices like intermittent fasting or short mono-diets (such as an apple fast) can trigger autophagy, where the body cleans out dysfunctional cells and may help "completely regenerate the immune system."
  • Gut healing: Removing inflammatory triggers (like gluten) and incorporating soothing, mucilaginous fibers (like flaxseed or therapeutic oats) to repair the intestinal lining.
  • Mind-body balance: Managing stress through practices like cold/hot immersion therapy, movement and deep sleep is critical, as chronic fear and a dominant "fight-or-flight" nervous system suppress regenerative immune functions.
  • Strategic supplementation: Incorporating immune-modulating compounds like beta-glucans from medicinal mushrooms and anti-inflammatory agents like curcumin from turmeric.
This holistic approach represents a profound empowerment, moving away from a fear-based model of disease defense. "What we need to do is maintain equanimity, eat a really good diet, reduce toxic exposure. This is the way we take control of our health," Ji asserted. True immunity is not a war to be won against the outside world, but a resilient state of balance cultivated from within.

Want to know more?

If you want to learn at your own pace and discover how to regenerate your health on your own schedule, you can access the full course by owning your copy of the "Regenerate Yourself Masterclass" package. Upon purchase, you will get the "Regenerate Yourself Masterclass" full course along with bonuses, including "The Regenerate Fitness Program," "The Regenerative Cooking Series," 10 exclusive expert-level bonus videos and six evidence-backed eBooks on healthy aging, detoxification and nutrition. BrighteonUniversity.com 1 BrightU.com BrightU.ai BrighteonUniversity.com 2
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